The role of chemokines in tissue inflammation and autoimmunity in renal diseases

被引:9
作者
Lloyd, C [1 ]
Gutierrez-Ramos, JC [1 ]
机构
[1] Millennium Pharmaceut Inc, Inflammat Div, Cambridge, MA 02139 USA
关键词
D O I
10.1097/00041552-199805000-00008
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Chemokines are an expanding family of chemoattractant polypeptides involved in the extravasation of leukocytes during the inflammatory process. This review highlights recent advances in the field, including the discovery of a new class of chemokines, and several novel receptors. In addition, the expanding role of chemokines in pathologic processes other than extravasation and their potential as therapeutic targets are discussed. (C) 1998 Rapid Science Ltd.
引用
收藏
页码:281 / 287
页数:7
相关论文
共 41 条
[1]   Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor [J].
Aramori, I ;
Zhang, J ;
Ferguson, SSG ;
Bieniasz, PD ;
Cullen, BR ;
Caron, MG .
EMBO JOURNAL, 1997, 16 (15) :4606-4616
[2]   ACTIVATION OF DUAL T-CELL SIGNALING PATHWAYS BY THE CHEMOKINE RANTES [J].
BACON, KB ;
PREMACK, BA ;
GARDNER, P ;
SCHALL, TJ .
SCIENCE, 1995, 269 (5231) :1727-1730
[3]   Blocking chemokine receptors [J].
Baggiolini, M ;
Moser, B .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (08) :1189-1191
[4]   Human chemokines: An update [J].
Baggiolini, M ;
Dewald, B ;
Moser, B .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :675-705
[5]   A new class of membrane-bound chemokine with a CX(3)C motif [J].
Bazan, JF ;
Bacon, KB ;
Hardiman, G ;
Wang, W ;
Soo, K ;
Rossi, D ;
Greaves, DR ;
Zlotnik, A ;
Schall, TJ .
NATURE, 1997, 385 (6617) :640-644
[6]   Chemokine receptors and HIV [J].
Broder, CC ;
Collman, RG .
JOURNAL OF LEUKOCYTE BIOLOGY, 1997, 62 (01) :20-29
[7]   alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats [J].
Chiao, H ;
Kohda, Y ;
McLeroy, P ;
Craig, L ;
Housini, I ;
Star, RA .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (06) :1165-1172
[8]  
Cockwell P, 1997, J AM SOC NEPHROL, V8, pA2104
[9]   A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor [J].
Doranz, BJ ;
GrovitFerbas, K ;
Sharron, MP ;
Mao, SH ;
Goetz, MB ;
Daar, ES ;
Doms, RW ;
OBrien, WA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (08) :1395-1400
[10]   Orchestrated information transfer underlying leukocyte endothelial interactions [J].
Ebnet, K ;
Kaldjian, EP ;
Anderson, AO ;
Shaw, S .
ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :155-177