Biomarkers of oxidative stress and antioxidant status in children born small for gestational age: Evidence of lipid peroxidation

被引:56
作者
Franco, Maria C. P.
Kawamoto, Elisa M.
Gorjao, Renata
Rastelli, Viviani M. F.
Curi, Rui
Scavone, Cristoforo
Sawaya, Ana Lydia
Fortes, Zuleica Bruno
Sesso, Ricardo
机构
[1] Univ Fed Sao Paulo, Sch Med, Dept Physiol, Div Nephrol, BR-04023900 Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Med, Inst Biomed Sci, BR-00508070 Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
D O I
10.1203/PDR.0b013e3180986d04
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Children born small for gestational age are known to be at increased risk for adult diseases such as hypertension, diabetes, and coronary heart disease. Oxidative stress is a common feature of these pathogenic conditions and can be the key link between size at birth and increased morbidity later in life. The purpose of this study was to analyze the parameters of lipoperoxidation and changes in antioxidant defense system as well as assess their relationship to birth weight. Concentrations of thiobarbituric-acid-reactive-substances and F-2-isoprostanes, total antioxidant status, and the activity of both superoxide dismutase and glutathione peroxidase were measured in 65 children (33 boys, 32 girls; ages 8-13 y). Thiobarbituric-acid-reactive-substances and F-2-isoprostane levels were significantly elevated in children born small for gestational age. Nevertheless, superoxide dismutase activity was significantly elevated in these children and the levels of both glutathione peroxidase activity and total antioxidant status were unchanged. Moreover, we found that systolic blood pressure was positively associated with thiobarbituric-acid-reactive-substances levels in race- and gender-adjusted models but not in a multivariable regression model. In conclusion, the current study revealed that there is evidence of oxidative stress in children born small for gestational age as supported by increased lipid peroxidation.
引用
收藏
页码:204 / 208
页数:5
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