Synthesis of novel ferrocenyl sugars and their antimalarial activities

被引：119

作者：

Itoh, T

Shirakami, S

Ishida, N

Yamashita, Y

Yoshida, T

Kim, HS

Wataya, Y

机构：

[1] Okayama Univ, Fac Educ, Dept Chem, Okayama 7008530, Japan

[2] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(00)00313-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of twelve types of novel ferrocenyl sugars and their biological properties towards the malaria parasite (P. falciparum) and mouse cancer cell (FM3A) are described. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1657 / 1659

页数：3

共 25 条

[1] SYNTHESIS OF SUGAR ORGANOMETALLIC CONJUGATES - FERROCENYL DERIVATIVES [J].

ADAM, MJ ;

HALL, LD .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1979, (19) :865-866

[2] SYNTHESIS OF SUGAR-ORGANOMETALLIC CONJUGATES - FERROCENYL MONOSACCHARIDE DERIVATIVES [J].

ADAM, MJ ;

HALL, LD .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1980, 58 (12) :1188-1197

[3] Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue [J].

Biot, C ;

Glorian, G ;

Maciejewski, LA ;

Brocard, JS ;

Domarle, O ;

Blampain, G ;

Millet, P ;

Georges, AJ ;

Abessolo, H ;

Dive, D ;

Lebibi, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (23) :3715-3718

[4] A new ferrocenemethyl-thymidine nucleoside: Synthesis, incorporation into oligonucleotides and optical spectroscopic studies on the resulting single strand, duplex and triplex structures. [J].

Bucci, E ;

De Napoli, L ;

Di Fabio, G ;

Messere, A ;

Montesarchio, D ;

Romanelli, A ;

Piccialli, G ;

Varra, M .

TETRAHEDRON, 1999, 55 (50) :14435-14450

[5] Ellagitannin chemistry. First total synthesis of the 2,3- and 4,6-coupled ellagitannin pedunculagin [J].

Feldman, KS ;

Smith, RS .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (08) :2606-2612

[6]

Garcia MM, 1997, TETRAHEDRON, V53, P12369

[7] CALAMITIC METALLOMESOGENS - METAL-CONTAINING LIQUID-CRYSTALS WITH RODLIKE SHAPES [J].

HUDSON, SA ;

MAITLIS, PM .

CHEMICAL REVIEWS, 1993, 93 (03) :861-885

[8] NEW METHOD OF KINETIC RESOLUTION OF AXIALLY CHIRAL BIARYL COMPOUNDS USING A SUGAR TEMPLATE [J].

ITOH, T ;

CHIKA, JI .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (16) :4968-4969

[9] Synthesis of trideca-O-methyl-alpha-pedunculagin. Diastereo-favoritism studies on intramolecular ester-cyclization of axially chiral diphenic acids with carbohydrate core [J].

Itoh, T ;

Chika, J ;

Shirakami, S ;

Ito, H ;

Yoshida, T ;

Kubo, Y ;

Uenishi, J .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (11) :3700-3705

[10] Redox active artificial ferrocenyl ellagitannins. Simple synthesis and their electrochemical properties [J].

Itoh, T ;

Shirakami, S ;

Nakao, Y ;

Yoshida, T .

CHEMISTRY LETTERS, 1998, (10) :979-980

← 1 2 3 →