Samarium diiodide-induced radical cyclization of oxime ether connected with formyl group: Synthesis of 4-pyrimidinyl- and 4-purinylpyrrolidin-3-ol nucleoside analogues

被引：52

作者：

Miyabe, H ^{[1
]}

Kanehira, S ^{[1
]}

Kume, K ^{[1
]}

Kandori, H ^{[1
]}

Naito, T ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Kobe, Hyogo 6588558, Japan

来源：

TETRAHEDRON | 1998年 / 54卷 / 22期

关键词：

D O I：

10.1016/S0040-4020(98)00274-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

SmI2-induced 5-exo-trig radical cyclization of oxime ether intramolecularly connected with the formyl group was found to be particularly effective for preparing cyclic trans-amino alcohol in good chemical yield with a high degree of stereoselectivity. Ils successful application to the synthesis of a novel class of 4-pyrimidinyl- and 4-purinylpyrrolidin-3-ol nucleoside analogues is also described. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：5883 / 5892

页数：10

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