Dynamic modeling of complex biological systems: a link between metabolic and macroscopic description

被引：31

作者：

Haag, JE

Wouwer, AV

Bogaerts, P

机构：

[1] Fac Polytech Mons, Serv Automat, B-7000 Mons, Belgium

[2] Free Univ Brussels, Serv Chim Gen & Biosyst, B-1050 Brussels, Belgium

来源：

MATHEMATICAL BIOSCIENCES | 2005年 / 193卷 / 01期

关键词：

biotechnology; mathematical modeling; model reduction; parameter estimation; non-linear systems;

D O I：

10.1016/j.mbs.2004.11.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this study, a class of dynamic models based on metabolic reaction pathways is analyzed, showing that systems with complex intracellular reaction networks can be represented by macroscopic reactions relating extracellular components only. Based on rigorous assumptions, the model reduction procedure is systematic and allows an equivalent 'input-output' representation of the system to be derived. The procedure is illustrated with a few examples. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：25 / 49

页数：25

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