Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP

被引：297

作者：

Ko, YH ^{[1
]}

Smith, BL

Wang, YC

Pomper, MG

Rini, DA

Torbenson, MS

Hullihen, J

Pedersen, PL

机构：

[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Art Appl Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 324卷 / 01期

关键词：

advanced cancers; liver/colon cancer; cancer therapy; 3-bromopyruvic acid; ATP depletion;

D O I：

10.1016/j.bbrc.2004.09.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A common feature of many advanced cancers is their enhanced capacity to metabolize glucose to lactic acid. In a challenging study designed to assess whether such cancers can be debilitated, we seeded hepatocellular carcinoma cells expressing the highly glycolytic phenotype into two different locations of young rats. Advanced cancers (2-3 cm) developed and were treated with the alkylating agent 3-bromopyruvate, a lactate/pyruvate analog shown here to selectively deplete ATP and induce cell death. In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：269 / 275

页数：7

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