Green tea and skin

被引:128
作者
Katiyar, SK [1 ]
Ahmad, N [1 ]
Mukhtar, H [1 ]
机构
[1] Case Western Reserve Univ, Dept Dermatol, Cleveland, OH 44106 USA
关键词
D O I
10.1001/archderm.136.8.989
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Objective: To discuss the current knowledge of polyphenolic compounds present in green tea as antiinflammatory, antioxidant, and anticarcinogenic in skin. Data Sources: References identified from bibliographies of pertinent articles, including our work in related fields. Study Selection and Delta Extraction: Articles were selected based on the use of green tea or its polyphenolic constituents for prevention against inflammation and cancer in the skin. Also discussed is the possible use of green tea to treat various inflammatory dermatoses. Data Synthesis: The polyphenolic compounds from green tea were tested against chemical carcinogenesis and photocarcinogenesis in murine skin. These green tea poly-phenols were found to afford protection against chemical carcinogenesis as well as photocarcinogenesis in mouse skin. A few experimental studies were conducted in human skin in our laboratory. Analysis of published studies demonstrates that green tea polyphenols have antiinflammatory and anticarcinogenic properties. These effects appear to correlate with antioxidant properties of green tea polyphenols. Conclusions: The outcome of the several experimental studies suggests that green tea possess anti-inflammatory and anticarcinogenic potential, which can be exploited against a variety of skin disorders. Although more clinical studies are needed, supplementation of skin care products with green tea may have a profound impact on various dskin disorders in the years to come.
引用
收藏
页码:989 / 994
页数:6
相关论文
共 64 条
[1]  
AGARWAL R, 1992, CANCER RES, V52, P3582
[2]   PROTECTION AGAINST ULTRAVIOLET-B RADIATION-INDUCED EFFECTS IN THE SKIN OF SKH-1 HAIRLESS MICE BY A POLYPHENOLIC FRACTION ISOLATED FROM GREEN TEA [J].
AGARWAL, R ;
KATIYAR, SK ;
KHAN, SG ;
MUKHTAR, H .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1993, 58 (05) :695-700
[3]  
AGARWAL R, 1993, OXIDATIVE STRESS DER, P207
[4]  
AGARWAL R, 1991, PHARM SKIN, P371
[5]   Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells [J].
Ahmad, N ;
Feyes, DK ;
Nieminen, AL ;
Agarwal, R ;
Mukhtar, H .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (24) :1881-1886
[6]   DIETARY CARCINOGENS AND ANTICARCINOGENS - OXYGEN RADICALS AND DEGENERATIVE DISEASES [J].
AMES, BN .
SCIENCE, 1983, 221 (4617) :1256-1264
[7]   MICRONUTRIENTS AND CANCER - TIME FOR ACTION [J].
BLOCK, G .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (11) :846-848
[8]   A ROLE FOR SUNLIGHT IN SKIN-CANCER - UV-INDUCED P53 MUTATIONS IN SQUAMOUS-CELL CARCINOMA [J].
BRASH, DE ;
RUDOLPH, JA ;
SIMON, JA ;
LIN, A ;
MCKENNA, GJ ;
BADEN, HP ;
HALPERIN, AJ ;
PONTEN, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) :10124-10128
[9]  
Challa A, 1998, J INVEST DERMATOL, V110, P695
[10]  
CONNEY AH, 1982, CANCER RES, V42, P4875