Osteoblasts in prostate cancer metastasis to bone

被引:451
作者
Logothetis, CJ
Lin, SH
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Genitourinary Oncol, Houston, TX 77030 USA
[2] Univ Texas, MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA
关键词
D O I
10.1038/nrc1528
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Metastasis to bone is common in lung, kidney, breast and prostate cancers. However, prostate cancer is unique in that bone is often the only clinically detectable site of metastasis, and the resulting tumours tend to be osteoblastic ( bone forming) rather than osteolytic (bone lysing). The interaction between host cells and metastatic cancer cells is an important component of organ-specific cancer progression. How can this knowledge lead to the development of more effective therapies?
引用
收藏
页码:21 / 28
页数:8
相关论文
共 84 条
[1]  
Ali O, 2003, HORM METAB RES, V35, P726
[2]  
[Anonymous], 1997, BIOCH BIOPHYSICA ACT
[3]   Bone morphogenetic protein 6 in skeletal metastases from prostate cancer and other common human malignancies [J].
Autzen, P ;
Robson, CN ;
Bjartell, A ;
Malcolm, AJ ;
Johnson, MI ;
Neal, DE ;
Hamdy, FC .
BRITISH JOURNAL OF CANCER, 1998, 78 (09) :1219-1223
[4]  
BASERGA R, 1995, CANCER RES, V55, P249
[5]   Functional interaction of beta-catenin with the transcription factor LEF-1 [J].
Behrens, J ;
vonKries, JP ;
Kuhl, M ;
Bruhn, L ;
Wedlich, D ;
Grosschedl, R ;
Birchmeier, W .
NATURE, 1996, 382 (6592) :638-642
[6]   High bone density due to a mutation in LDL-receptor-related protein 5 [J].
Boyden, LM ;
Mao, JH ;
Belsky, J ;
Mitzner, L ;
Farhi, A ;
Mitnick, MA ;
Wu, DQ ;
Insogna, K ;
Lifton, RP .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (20) :1513-1521
[7]   Osteoclast differentiation and activation [J].
Boyle, WJ ;
Simonet, WS ;
Lacey, DL .
NATURE, 2003, 423 (6937) :337-342
[8]  
Brown JM, 2001, CLIN CANCER RES, V7, P2977
[9]   Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: A randomized, phase II, placebo-controlled trial [J].
Carducci, MA ;
Padley, RJ ;
Breul, J ;
Vogelzang, NJ ;
Zonnenberg, BA ;
Daliani, DD ;
Schulman, CC ;
Nabulsi, AA ;
Humerickhouse, RA ;
Weinberg, MA ;
Schmitt, JL ;
Nelson, JB .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (04) :679-689
[10]   STIMULATION OF HUMAN PROSTATIC-CARCINOMA CELL-GROWTH BY FACTORS PRESENT IN HUMAN-BONE MARROW [J].
CHACKALROY, M ;
NIEMEYER, C ;
MOORE, M ;
ZETTER, BR .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (01) :43-50