Exegeses - Transactivation of repair genes by BRCA1

被引：18

作者：

El-Deiry, WS ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

来源：

CANCER BIOLOGY & THERAPY | 2002年 / 1卷 / 05期

关键词：

D O I：

10.4161/cbt.1.5.162

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies have identified a link between the BRCA1 tumor suppressor and transcriptional regulation of a group of genes involved in nucleotide excision repair. There is some controversy regarding the precise mechanism of upregulation of XPE DDB2 or XPC by BRCA1, with some evidence suggesting that p53 is involved in their regulation. Some evidence suggests BRCA1 may stabilize p53 and direct regulation of DNA repair genes, although how BRCA1 stabilizes p53 remains unclear and whether BRCA1 can upregulate DNA repair genes in a p53-independent manner remains a possibility. A transcriptional component to the action of BRCA1 and involvement of XP genes brings up new and interesting questions about breast cancer development and therapy.

引用

页码：490 / 491

页数：2

共 10 条

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