Increased neuropeptide Y mRNA expression in striatum in Parkinson's disease

被引:44
作者
Cannizzaro, C
Tel, BC
Rose, S
Zeng, BY
Jenner, P [1 ]
机构
[1] Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, Neurodegenerat Dis Res Ctr, London SE1 1UL, England
[2] Univ Palermo, Dept Pharmacol Sci, Palermo, Italy
来源
MOLECULAR BRAIN RESEARCH | 2003年 / 110卷 / 02期
关键词
neuropeptide Y (NPY); in situ hybridisation; striatum; Parkinson's disease; RAT STRIATUM; HUNTINGTONS-DISEASE; CONTAINING NEURONS; BASAL GANGLIA; HUMAN-BRAIN; SOMATOSTATIN; SYSTEMS; NPY;
D O I
10.1016/S0169-328X(02)00555-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
High levels of neuropeptide Y (NPY) are found in basal ganglia where it is co-localised with somatostatin (SOM) and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH/d) in a population of striatal GABA containing interneurones. Although alterations occur in the levels of various neuropeptides in basal ganglia in Parkinson's disease (PD), it is not known whether NPY is affected. Using in situ hybridisation immunohistochemistry, we have examined the distribution of NPY mRNA in the caudate nucleus, putamen and nucleus accumbens of normal individuals and patients with PD. NPY mRNA was weakly expressed in the caudate nucleus, putamen and nucleus accumbens in normal individuals with a scattered labelling of neurones. However, there was no regional localisation within any brain area and no obvious differences between brain regions. In PD, the number of NPY mRNA-expressing cells was increased as was the density of the silver grains overlying each positive cell. The increase was more pronounced in the nucleus accumbens and in the ventral part of the caudate nucleus. The increase in NPY mRNA expression observed in patients with PD may reflect the loss of dopaminergic tone on striatal NPY containing interneurones, although a role for chronic L-DOPA therapy cannot be ruled out. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:169 / 176
页数:8
相关论文
共 31 条
[1]   DISSOCIATION OF NEUROPEPTIDE-Y AND SOMATOSTATIN IN PARKINSONS-DISEASE [J].
ALLEN, JM ;
CROSS, AJ ;
CROW, TJ ;
JAVOYAGID, F ;
AGID, Y ;
BLOOM, SR .
BRAIN RESEARCH, 1985, 337 (01) :197-200
[2]   THE EFFECT OF NEUROPEPTIDE-Y ON STRIATAL CATECHOLAMINES [J].
BEAL, MF ;
FRANK, RC ;
ELLISON, DW ;
MARTIN, JB .
NEUROSCIENCE LETTERS, 1986, 71 (01) :118-123
[3]   SOMATOSTATIN AND NEUROPEPTIDE-Y CONCENTRATIONS IN PATHOLOGICALLY GRADED CASES OF HUNTINGTONS-DISEASE [J].
BEAL, MF ;
MAZUREK, MF ;
ELLISON, DW ;
SWARTZ, KJ ;
MCGARVEY, U ;
BIRD, ED ;
MARTIN, JB .
ANNALS OF NEUROLOGY, 1988, 23 (06) :562-569
[4]   NEUROPEPTIDE-Y - REGIONAL DISTRIBUTION CHROMATOGRAPHIC CHARACTERIZATION AND IMMUNOHISTOCHEMICAL DEMONSTRATION IN POST-MORTEM HUMAN-BRAIN [J].
DAWBARN, D ;
HUNT, SP ;
EMSON, PC .
BRAIN RESEARCH, 1984, 296 (01) :168-173
[5]   SURVIVAL OF BASAL GANGLIA NEUROPEPTIDE Y-SOMATOSTATIN NEURONS IN HUNTINGTONS-DISEASE [J].
DAWBARN, D ;
DEQUIDT, ME ;
EMSON, PC .
BRAIN RESEARCH, 1985, 340 (02) :251-260
[6]   Selective increase in somatostatin mRNA expression in human basal ganglia in Parkinson's disease [J].
Eve, DJ ;
Nisbet, AP ;
Kingsbury, AE ;
Temlett, J ;
Marsden, CD ;
Foster, OJF .
MOLECULAR BRAIN RESEARCH, 1997, 50 (1-2) :59-70
[7]   SOMATOSTATIN-28 AND NEUROPEPTIDE-Y INNERVATION IN THE SEPTAL AREA AND RELATED CORTICAL AND SUBCORTICAL STRUCTURES OF THE HUMAN-BRAIN - DISTRIBUTION, RELATIONSHIPS AND EVIDENCE FOR DIFFERENTIAL COEXISTENCE [J].
GASPAR, P ;
BERGER, B ;
LESUR, A ;
BORSOTTI, JP ;
FEBVRET, A .
NEUROSCIENCE, 1987, 22 (01) :49-73
[8]   THE NEOSTRIATAL MOSAIC - COMPARTMENTALIZATION OF CORTICOSTRIATAL INPUT AND STRIATONIGRAL OUTPUT SYSTEMS [J].
GERFEN, CR .
NATURE, 1984, 311 (5985) :461-464
[9]   NEUROPEPTIDE-Y EFFECTOR SYSTEMS - PERSPECTIVES FOR DRUG DEVELOPMENT [J].
GRUNDEMAR, L ;
HAKANSON, R .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (05) :153-159
[10]   DOPAMINE-RECEPTORS IN PARKINSONS-DISEASE [J].
GUTTMAN, M .
NEUROLOGIC CLINICS, 1992, 10 (02) :377-386