The chemokine system in diverse forms of macrophage activation and polarization

被引：5115

作者：

Mantovani, A ^{[1
]}

Sica, A

Sozzani, S

Allavena, P

Vecchi, A

Locati, M

机构：

[1] Univ Milan, Inst Gen Pathol, Ctr Eccellenza Innovaz Diagnost & Terapeut, IDET, I-20133 Milan, Italy

[2] Ist Ric Farmacol Mario Negri, I-20157 Milan, Italy

[3] Univ Brescia, Sect Gen Pathol & Immunol, Dept Biotechnol & Biomed Sci, I-25123 Brescia, Italy

来源：

TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 12期

关键词：

D O I：

10.1016/j.it.2004.09.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1 M2a, M2b, M2c), which represent extremes of a continuum. In particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.

引用

页码：677 / 686

页数：10

共 71 条

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