Serum microminerals and the indices of lipid metabolism in an apparently healthy population

Serum copper and zinc concentrations were measured in 560 apparently healthy Kuwaitis (238 males and 322 females) aged 15-80 years to assess micromineral effect on the indices of lipid metabolism. Following the recommended guidelines of the European Atherosclerosis Society (EAS) and the National Cholesterol Education Program Expert Panel (NCEPEP), the incidence of dyslipidemia was assessed from enzymatic assay data of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) concentrations. Males had significantly lower TC (P = 0.029) and HDL-C (P < 0.0001) levels than females, while TG were significantly (P = 0.023) lower in females. The prevalence of hypercholesterolemia, hypertriglyceridemia, elevated LDL-C, and low HDL-C levels were 35, 30, 22, and 13%, respectively. Copper did not correlate with zinc (r = -0.067, P = 0.135) but was positively associated with TC (r = 0.196, P < 0.0001), LDL-C (r = 0.134, P = 0.003), TG (r = 0.092, P = 0.039), and age (r = 0.281, P < 0.0001). It is concluded that unlike in animal studies, copper excess in humans is associated with hyperlipidemia and therefore will predispose to atherosclerosis. J. Clin. Lab. Anal. 17:61-65, 2003. (C) 2003 Wiley-Liss, Inc.