Symptomatic gastro-oesophageal reflux, arousals and sleep quality in patients undergoing polysomnography for possible obstructive sleep apnoea

被引:32
作者
Guda, N [1 ]
Partington, S [1 ]
Vakil, N [1 ]
机构
[1] Univ Wisconsin, Sch Med, Aurora Sinai Med Ctr, Milwaukee, WI 53233 USA
关键词
D O I
10.1111/j.1365-2036.2004.02263.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Introduction: Nocturnal acid reflux is common and could disturb sleep by causing arousals that fragment sleep. Aim: To determine the prevalence of gastro-oesophageal reflux symptoms and their association with arousals. stages of sleep and quality of life in patients undergoing evaluation for excessive daytime sleepiness and obstructive sleep apnoea. Methods: Ninety-four consecutive patients with excessive daytime sleepiness were prospectively studied. Patients completed the gastrointestinal symptom rating scale, a validated symptom questionnaire for reflux disease and a disease-specific quality of life questionnaire, the sleep apnoea quality of life index and then underwent overnight polysomnography, which was read in a blinded manner. Results: There were 40 males and 54 females with a mean age of 47 13 years. Reflux symptoms were present in 63 of the 94 (67%) patients. Patients with reflux symptoms had significantly more arousals from sleep 43 +/- 70/h than those without (20 +/- 24/h; P = 0.03). The sleep duration during the second stage of sleep was shorter (44 +/- 21%) for those with reflux symptoms than those without (52 +/- 12%; P = 0.03). Patients with reflux spent significantly shorter periods in stage 11 sleep (44 21%) than those without (52 12%,; P = 0.03). The sleep-related quality of life score in patients with gastro-oesophageal reflux (3.1 +/- 1.1) was significantly lower than in patients without reflux (3.7 +/- 1.0; P = 0.02). Regression analysis demonstrated a significant inverse correlation between quality of life and reflux symptom score (P 0.002) and total spontaneous arousals (P = 0.04). Conclusions: Gastro-oesophageal reflux is common in patients with sleep disorders, is associated with increased arousal, decreased durations spent in the deeper stages of sleep and poorer sleep-related quality of life.
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页码:1153 / 1159
页数:7
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