Side-chain hydrophobicity controls the activity of proton channel forming rigid rod-shaped polyols

被引:41
作者
Ni, CY [1 ]
Matile, S [1 ]
机构
[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA
关键词
D O I
10.1039/a708841h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Increased activity, facile incorporation into lipid bilayers and intact active structure and transport selectivity are the consequences of modifications of the side-chain hydrophobicity of a proton channel-forming octa(p-phenylene).
引用
收藏
页码:755 / 756
页数:2
相关论文
共 9 条
  • [1] ONE-SIDED ACTION OF AMPHOTERICIN-B ON CHOLESTEROL-CONTAINING MEMBRANES IS DETERMINED BY ITS SELF-ASSOCIATION IN THE MEDIUM
    BOLARD, J
    LEGRAND, P
    HEITZ, F
    CYBULSKA, B
    [J]. BIOCHEMISTRY, 1991, 30 (23) : 5707 - 5715
  • [2] Synthetic organic chemical models for transmembrane channels
    Gokel, GW
    Murillo, O
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (09) : 425 - 432
  • [3] Ladokhin AS, 1997, METHOD ENZYMOL, V278, P462
  • [4] A synthetic transmembrane channel active in lipid bilayers
    Meillon, JC
    Voyer, N
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (09): : 967 - 969
  • [5] HYDROGEN-BONDED CHAIN MECHANISMS FOR PROTON CONDUCTION AND PROTON PUMPING
    NAGLE, JF
    TRISTRAMNAGLE, S
    [J]. JOURNAL OF MEMBRANE BIOLOGY, 1983, 74 (01) : 1 - 14
  • [6] Toward biomimetic ion channels formed by rigid-rod molecules: Length-dependent ion-transport activity of substituted oligo(p-phenylene)s
    Sakai, N
    Brennan, KC
    Weiss, LA
    Matile, S
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (37) : 8726 - 8727
  • [7] THE OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION - A NEW LIGAND CLASS AND A PROCESS IMPROVEMENT
    SHARPLESS, KB
    AMBERG, W
    BENNANI, YL
    CRISPINO, GA
    HARTUNG, J
    JEONG, KS
    KWONG, HL
    MORIKAWA, K
    WANG, ZM
    XU, DQ
    ZHANG, XL
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (10) : 2768 - 2771
  • [8] Oligo-THF peptides: Synthesis, membrane insertion, and studies of ion channel activity
    Wagner, H
    Harms, K
    Koert, U
    Meder, S
    Boheim, G
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (22): : 2643 - 2646
  • [9] Rigid rod-shaped polyols: Functional nonpeptide models for transmembrane proton channels
    Weiss, LA
    Sakai, N
    Ghebremariam, B
    Ni, CY
    Matile, S
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (50) : 12142 - 12149