Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

被引：282

作者：

Nakamura, T

Uramura, K

Nambu, T

Yada, T

Goto, K

Yanagisawa, M

Sakurai, T ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Basic Med Sci, Dept Pharmacol, Tsukuba, Ibaraki 3058575, Japan

[2] Kagoshima Univ, Fac Med, Dept Neuropsychiat, Kagoshima 8908520, Japan

[3] Kagoshima Univ, Fac Med, Dept Physiol, Kagoshima 908520, Japan

[4] Natl Inst Physiol Sci, Lab Intracellular Metab, Okazaki, Aichi 4448585, Japan

[5] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

[6] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75235 USA

来源：

BRAIN RESEARCH | 2000年 / 873卷 / 01期

关键词：

hyperlocomotion; stereotypy; dopamine; ventral tegmental area; orexin;

D O I：

10.1016/S0006-8993(00)02555-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We demonstrated involvement of the ventral tegmental area (VTA) dopaminergic system in orexin-induced hyperlocomotion and stereotypy in rats. in double-label immunohistochemical study of rat brain, we found that tyrosine hydroxylase (TH)-immunoreactive cells in the VTA received innervation from orexin immunoreactive-fibers. Orexin-A induced an increase in [Ca2+](i) in isolated A10 dopamine neurons in a dose-dependent manner. Ln behavioral studies, we found that orexin-A induced hyperlocomotion, stereotypy and grooming behavior when administered centrally in rats, and these effects were abolished by dopamine D-2 (haloperidol and sulpiride) or D-1 (SCH23390) antagonists. These results suggest that the orexin-induced hyperlocomotion. stereotypy and grooming behavior are mediated by the dopaminergic system and this pathway might be involved in orexin-induced emotional responses. (C) 2000 Elsevier Science B.V. All rights reserved.

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页码：181 / 187

页数：7

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