Liraglutide

被引:142
作者
Drucker, Daniel J. [1 ]
Dritselis, Argyris [2 ]
Kirkpatrick, Peter
机构
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[2] IMS Hlth, London NW1 6JB, England
关键词
INCRETIN-BASED THERAPIES; GLUCAGON-LIKE PEPTIDE-1; OPEN-LABEL; TYPE-2; EXENATIDE; METFORMIN; COMBINATION; EFFICACY; PLACEBO; SAFETY;
D O I
10.1038/nrd3148
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In January 2010, liraglutide (Victoza; Novo Nordisk) — an injectable glucagon-like peptide 1 receptor agonist — was approved by the US FDA to improve glycaemic control in adults with type 2 diabetes mellitus.
引用
收藏
页码:267 / 268
页数:2
相关论文
共 17 条
[1]   Cardiovascular consequences of drugs used for the treatment of diabetes: potential promise of incretin-based therapies [J].
Ban, Kiwon ;
Hui, Sonya ;
Drucker, Daniel J. ;
Husain, Mansoor .
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, 2009, 3 (04) :245-259
[2]   One-year Treatment With Exenatide Improves β-Cell Function, Compared With Insulin Glargine, in Metformin-Treated Type 2 Diabetic Patients A randomized, controlled trial [J].
Bunck, Mathijs C. ;
Diamant, Michaela ;
Corner, Anja ;
Eliasson, Bjorn ;
Malloy, Jaret L. ;
Shaginian, Rimma M. ;
Deng, Wei ;
Kendall, David M. ;
Taskinen, Marja-Riitta ;
Smith, Ulf ;
Yki-Jarvinen, Hannele ;
Heine, Robert J. .
DIABETES CARE, 2009, 32 (05) :762-768
[3]   Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) [J].
Buse, John B. ;
Rosenstock, Julio ;
Sesti, Giorgio ;
Schmidt, Wolfgang E. ;
Montanya, Eduard ;
Brett, Jason H. ;
Zychma, Marcin ;
Blonde, Lawrence .
LANCET, 2009, 374 (9683) :39-47
[4]   Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study [J].
Drucker, Daniel J. ;
Buse, John B. ;
Taylor, Kristin ;
Kendall, David M. ;
Trautmann, Michael ;
Zhuang, Dangliang ;
Porter, Lisa .
LANCET, 2008, 372 (9645) :1240-1250
[5]   Incretin-Based Therapies for the Treatment of Type 2 Diabetes: Evaluation of the Risks and Benefits [J].
Drucker, Daniel J. ;
Sherman, Steven I. ;
Gorelick, Fred S. ;
Bergenstal, Richard M. ;
Sherwin, Robert S. ;
Buse, John B. .
DIABETES CARE, 2010, 33 (02) :428-433
[6]   Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial [J].
Garber, Alan ;
Henry, Robert ;
Ratner, Robert ;
Garcia-Hernandez, Pedro A. ;
Rodriguez-Pattzi, Hiromi ;
Olvera-Alvarez, Israel ;
Hale, Paula M. ;
Zdravkovic, Milan ;
Bode, Bruce .
LANCET, 2009, 373 (9662) :473-481
[7]  
*IMS HLTH, 2009, IMS MIDAS
[8]   Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration [J].
Knudsen, LB ;
Nielsen, PF ;
Huusfeldt, PO ;
Johansen, NL ;
Madsen, K ;
Pedersen, FZ ;
Thogersen, H ;
Wilken, M ;
Agerso, H .
JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (09) :1664-1669
[9]  
KNUDSEN LB, 2010, ENDOCRINOLOGY 0304, DOI DOI 10.1210/EN.2009-1272
[10]   Incretin-based therapies for type 2 diabetes mellitus [J].
Lovshin, Julie A. ;
Drucker, Daniel J. .
NATURE REVIEWS ENDOCRINOLOGY, 2009, 5 (05) :262-269