Crystallographic and spectroscopic characterization of a nonheme Fe(IV)=O complex

被引：797

作者：

Rohde, JU

In, JH

Lim, MH

Brennessel, WW

Bukowski, MR

Stubna, A

Münck, E

Nam, W

Que, L

机构：

[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Ctr Met Biocatalysis, Minneapolis, MN 55455 USA

[3] Ewha Womans Univ, Dept Chem, Seoul 120750, South Korea

[4] Ewha Womans Univ, Div Mol Life Sci, Seoul 120750, South Korea

[5] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA

来源：

SCIENCE | 2003年 / 299卷 / 5609期

关键词：

D O I：

10.1126/science.299.5609.1037

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Following the heme paradigm, it is often proposed that dioxygen activation by nonheme monoiron enzymes involves an iron(IV)=oxo intermediate that is responsible for the substrate oxidation step. Such a transient species has now been obtained from a synthetic complex with a nonheme macrocyclic ligand and characterized spectroscopically. Its high-resolution crystal structure reveals an iron-oxygen bond length of 1.646(3) angstroms, demonstrating that a terminal iron(IV)=oxo unit can exist in a nonporphyrin ligand environment and [ending credence to proposed mechanisms of nonheme iron catalysis.

引用

页码：1037 / 1039

页数：3

共 34 条

[1] Mechanism of the methane → methanol conversion reaction catalyzed by methane monooxygenase:: A density functional study [J].