The functional outcome of shunting H-Tx rat pups at different ages

被引:18
作者
Hawkins, D
Bowers, TM
Bannister, CM
Miyan, JA
机构
[1] Univ Manchester, Inst Sci & Technol, Dept Biomol Sci, Manchester M60 1QD, Lancs, England
[2] Univ Manchester, Booth Hall Childrens Hosp, Sch Med, Dept Paediat Neurosurg, Manchester M9 7AA, Lancs, England
关键词
H-Tx rat; hydrocephalus; learning and memory; maze training;
D O I
10.1055/s-2008-1071206
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Normal, untreated hydrocephalic and CSF shunted hydrocephalic Texas (H-Tx) rat pups at different ages and Sprague-Dawley controls were tested for spatial teaming and memory acquisition in an 8-arm radial maze. Shunting 5 day old hydrocephalic pups improved their performance to the level of that of "normal" littermates, whereas shunting at 10 days produced no improvement, and the performance of these animals was comparable to that of the untreated hydrocephalics. None of the H-Tx rats, whether treated, untreated or "normal", performed as well as the Sprague-Dawley controls. These findings suggest that shunting prior to skull plate fusion, which occurs at approximately the tenth postnatal day, is capable of protecting brain function involved in memory and learning. The poor functional scores achieved by the "normal" as well as the treated and untreated H-Tx animals compared to the control Sprague-Dawleys, raises the possibility that the H-Tx rat has brain deficits in addition to those caused by hydrocephalus.
引用
收藏
页码:31 / 34
页数:4
相关论文
共 6 条
[1]   THE CEREBRAL-CORTEX IN CONGENITAL HYDROCEPHALUS IN THE H-TX RAT - A QUANTITATIVE LIGHT-MICROSCOPY STUDY [J].
JONES, HC ;
BUCKNALL, RM ;
HARRIS, NG .
ACTA NEUROPATHOLOGICA, 1991, 82 (03) :217-224
[2]   INHERITED PRENATAL HYDROCEPHALUS IN THE H-TX RAT - A MORPHOLOGICAL-STUDY [J].
JONES, HC ;
BUCKNALL, RM .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1988, 14 (04) :263-274
[3]   CEREBROSPINAL-FLUID PRESSURE IN 10-DAY-OLD RATS WITH CONGENITAL HYDROCEPHALUS [J].
KAISER, G ;
JONES, HC .
EUROPEAN JOURNAL OF PEDIATRIC SURGERY, 1991, 1 :20-22
[4]  
MORRISEY R, 1996, EUR J PEDIAT SURG S1, V6, P30
[5]  
OLTON DS, 1976, J EXP BRAIN RES, V41, P380
[6]  
SUDA K, HYDROCEPHALUS PATHOG, P10