The role of aquaporin-4 in the blood-brain barrier development and integrity: Studies in animal and cell culture models

被引:168
作者
Nicchia, GP
Nico, B
Camassa, LMA
Mola, MG
Loh, N
Dermietzel, R
Spray, DC
Svelto, M
Friger, A
机构
[1] Univ Bari, Dept Gen & Environm Physiol, I-70126 Bari, Italy
[2] Univ Bari, Ctr Excellence Comparat Gen, I-70126 Bari, Italy
[3] Univ Bari, Sch Med, Dept Human Anat & Histol, I-70124 Bari, Italy
[4] Univ Oxford, Dept Human Anat & Genet, Oxford OX1 3QX, England
[5] Ruhr Univ Bochum, Dept Neuroanat & Mol Brain Res, D-44801 Bochum, Germany
[6] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10464 USA
关键词
aquaporins; brain edema; co-cultures; astrocytes; mdx; muscular dystrophy;
D O I
10.1016/j.neuroscience.2004.07.055
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Aquaporin-4 (AQP4) is the major water channel expressed in brain perivascular astrocyte processes. Although the role of AQP4 in brain edema has been extensively investigated, little information exists regarding its functional role at the blood-brain barrier (BBB). The purpose of this work is to integrate previous and recent data regarding AQP4 expression during BBB formation and depending on BBB integrity, using several experimental models. Results from studies on the chick optic tectum, a well-established model of BBB development, and the effect of lipopolysaccharide on the BBB integrity and on perivascular AQP4 expression have been analyzed and discussed. Moreover, data on the BBB structure and AQP4 expression in murine models of Duchenne muscular dystrophy are reviewed. In particular, published results obtained from mdX(3cv) mice have been analyzed together with new data obtained from mdx mice in which all the dystrophin isoforms including DP71 are strongly reduced. Finally, the role of the endothelial component on AQP4 cellular expression and distribution has been investigated using rat primary astrocytes and brain capillary endothelial cell co-cultures as an in vitro model of BBB. (C) 2004 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:935 / 945
页数:11
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