Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis

被引：21

作者：

Arya, R ^{[1
]}

Quevillon, S ^{[1
]}

Joseph, R ^{[1
]}

Wei, CQ ^{[1
]}

Gan, Z ^{[1
]}

Parisien, M ^{[1
]}

Sesmilo, E ^{[1
]}

Reddy, RT ^{[1
]}

Chen, ZX ^{[1
]}

Durieux, R ^{[1
]}

Laforce, D ^{[1
]}

Campeau, LC ^{[1
]}

Khadem, S ^{[1
]}

Couve-Bonnaire, S ^{[1
]}

Kumar, R ^{[1
]}

Sharma, U ^{[1
]}

Leek, DM ^{[1
]}

Daroszewska, M ^{[1
]}

Barnes, ML ^{[1
]}

机构：

[1] Natl Res Council Canada, Steacie Inst Mol Sci, Chem Biol Program, Ottawa, ON K1A 0R6, Canada

来源：

PURE AND APPLIED CHEMISTRY | 2005年 / 77卷 / 01期

关键词：

D O I：

10.1351/pac200577010163

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Due to the growing interest in small molecules that could help in understanding protein-protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has grown significantly. Many of these pathways are highly complex and present tremendous challenges with the use of classical tools. A rapid access to natural product-like small molecules having structural complexity and diversity is crucial for systematically dissecting the functions of complex protein networking and understanding cell signaling pathways. The complex nature, the three-dimensional architecture, and the number of protein binding functional groups presented in three-dimensional arrays are some of the attractive features to incorporate in small-molecule chemical probes to be used as modulators of protein function.

引用

页码：163 / 178

页数：16

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