Protein adsorption to hydrocephalus shunt catheters: CSF protein adsorption

Objective-To assess the quantity and nature of the proteins that adsorb to hydrocephalus shunt catheters after implantation, and to determine whether sufficient could accumulate to obstruct the catheter. Design-Elution of proteins from 102 explanted shunt catheters, with protein assay and electrophoresis of the eluate, and scanning electron microscopy (SEM) of the catheters. Results-The amount of protein elutable was extremely low, and significant protein, apart from a thin film, was not found on SEM. Qualitative analysis disclosed that most of the adsorbed protein was albumin. Conclusions-Protein deposition on hydrocephalus catheters does not occur in sufficient quantities to cause catheter obstruction.