Deficiency of Mbd2 suppresses intestinal tumorigenesis

被引：135

作者：

Sansom, OJ

Berger, J

Bishop, SM

Hendrich, B

Bird, A ^{[1
]}

Clarke, AR

机构：

[1] Cardiff Univ, Cardiff Sch Biosci, Cardiff, S Glam, Wales

[2] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

NATURE GENETICS | 2003年 / 34卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ng1155

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene silencing through de novo methylation of CpG island promoters contributes to cancer. We find that Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the mouse intestine. As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance.

引用

收藏

页码：145 / 147

页数：3

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