Monoclonal antibody therapies - a 'constant' threat to cancer

被引：60

作者：

Houghton, AN ^{[1
]}

Scheinberg, DA ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 04期

关键词：

D O I：

10.1038/74621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many mechanisms have been proposed for the positive effects of monoclonal antibodies in cancer therapy. New data indicate that both the variable, antigen-binding region of an antibody and the Fc region are capable of influencing anti-cancer immunity (pages 443-446).

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页码：373 / 374

页数：2

相关论文

共 10 条

[1] Fc receptors are required in passive and active immunity to melanoma [J].

Clynes, R ;

Takechi, Y ;

Moroi, Y ;

Houghton, A ;

Ravetch, JV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (02) :652-656

[2] Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets [J].

Clynes, RA ;

Towers, TL ;

Presta, LG ;

Ravetch, JV .

NATURE MEDICINE, 2000, 6 (04) :443-446

[3]

Dinney CPN, 1997, CLIN CANCER RES, V3, P161

[4] DOWN-MODULATION OF AN ONCOGENE PROTEIN PRODUCT AND REVERSION OF THE TRANSFORMED PHENOTYPE BY MONOCLONAL-ANTIBODIES [J].

DREBIN, JA ;

LINK, VC ;

STERN, DF ;

WEINBERG, RA ;

GREENE, MI .

CELL, 1985, 41 (03) :695-706

[5] CONTINUOUS CULTURES OF FUSED CELLS SECRETING ANTIBODY OF PREDEFINED SPECIFICITY [J].

KOHLER, G ;

MILSTEIN, C .

NATURE, 1975, 256 (5517) :495-497

[6]

MASUI H, 1984, CANCER RES, V44, P1002

[7] Rationally designed anti-HER2/neu peptide mimetic disables p185HER2/neu tyrosine kinases in vitro and in vivo [J].

Park, BW ;

Zhang, HT ;

Wu, CJ ;

Berezov, A ;

Zhang, X ;

Dua, R ;

Wang, Q ;

Kao, G ;

O'Rourke, DM ;

Greene, MI ;

Murali, R .

NATURE BIOTECHNOLOGY, 2000, 18 (02) :194-198

[8] PHASE-I TRIAL OF A MOUSE MONOCLONAL-ANTIBODY AGAINST GD3 GANGLIOSIDE IN PATIENTS WITH MELANOMA - INDUCTION OF INFLAMMATORY RESPONSES AT TUMOR SITES [J].

VADHANRAJ, S ;

CORDONCARDO, C ;

CARSWELL, E ;

MINTZER, D ;

DANTIS, L ;

DUTEAU, C ;

TEMPLETON, MA ;

OETTGEN, HF ;

OLD, LJ ;

HOUGHTON, AN .

JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (10) :1636-1648

[9]

VUIST WMJ, 1994, BLOOD, V83, P899

[10]

WALDMANN TA, 1988, HARVEY LECT, V82, P1