The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation

被引：23

作者：

Bekisz, Jonathan M. ^{[1
,2
]}

Lopez, Christopher D. ^{[3
,4
,5
]}

Corciulo, Carmen ^{[4
]}

Mediero, Aranzazu ^{[4
,6
]}

Coelho, Paulo G. ^{[2
,5
]}

Witek, Lukasz ^{[5
]}

Flores, Roberto L. ^{[2
]}

Cronstein, Bruce N. ^{[1
,4
]}

机构：

[1] NYU, Sch Med, 550 First Ave,MSB 521, New York, NY 10016 USA

[2] NYU, Sch Med, Hansjorg Wyss Dept Plast Surg, 307 East 33rd St, New York, NY 10016 USA

[3] Icahn Sch Med Mt Sinai, 1468 Madison Ave, New York, NY 10029 USA

[4] NYU, Sch Med, Div Translat Med, 550 First Ave, New York, NY 10016 USA

[5] NYU, Coll Dent, Dept Biomat & Biomimet, 433 First Ave, New York, NY 10010 USA

[6] IIS Fdn Jimenez Diaz UAM, Bone & Joint Res Unit, Madrid, Spain

来源：

INFLAMMATION | 2018年 / 41卷 / 04期

关键词：

tissue engineering; chondrocyte; cartilage; regeneration; ANTIINFLAMMATORY MECHANISM; DEAMINASE INHIBITOR; DOWN-REGULATION; A2A RECEPTOR; RELEASE; OSTEOARTHRITIS; DIFFERENTIATION; METHOTREXATE; CHONDROCYTES; STIMULATION;

D O I：

10.1007/s10753-018-0781-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Adenosine receptor activation has been explored as a modulator of the inflammatory process that propagates osteoarthritis. It has been reported that cartilage has enhanced regenerative potential when influenced by adenosine receptor activation. As adenosine's role in maintaining chondrocyte homeostasis at the cellular and molecular levels is explored, successful in vivo applications of adenosine delivery for cartilage repair continue to be reported. This review summarizes the role adenosine receptor ligation plays in chondrocyte homeostasis and regeneration of articular cartilage damaged in osteoarthritis. It also reports on all the modalities reported for delivery of adenosine through in vivo applications.

引用

页码：1135 / 1141

页数：7

共 57 条

[1]

Liposomal drug delivery systems: From concept to clinical applications [J].

Allen, Theresa M. ;

Cullis, Pieter R. .

ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (01) :36-48

[2]

Effects of adenosine on bacterial lipopolysaccharide- and interleukin 1-induced nitric oxide release from equine articular chondrocytes [J].

Benton, HP ;

MacDonald, MH ;

Tesch, AM .

AMERICAN JOURNAL OF VETERINARY RESEARCH, 2002, 63 (02) :204-210

[3]

Polydeoxyribonucleotide Reduces Cytokine Production and the Severity of Collagen-Induced Arthritis by Stimulation of Adenosine A2A Receptor [J].

Bitto, Alessandra ;

Polito, Francesca ;

Irrera, Natasha ;

D'Ascola, Angela ;

Avenoso, Angela ;

Nastasi, Giancarlo ;

Campo, Giuseppe M. ;

Micali, Antonio ;

Bagnato, Gianfilippo ;

Minutoli, Letteria ;

Marini, Herbert ;

Rinaldi, Mariagrazia ;

Squadrito, Francesco ;

Altavilla, Domenica .

ARTHRITIS AND RHEUMATISM, 2011, 63 (11) :3364-3371

[4]

Pathological overproduction: the bad side of adenosine [J].

Borea, Pier Andrea ;

Gessi, Stefania ;

Merighi, Stefania ;

Vincenzi, Fabrizio ;

Varani, Katia .

BRITISH JOURNAL OF PHARMACOLOGY, 2017, 174 (13) :1945-1960

[5]

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects? [J].

Borea, Pier Andrea ;

Gessi, Stefania ;

Merighi, Stefania ;

Varani, Katia .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2016, 37 (06) :419-434

[6]

Adenosine A2A receptor activation and hyaluronan fragment inhibition reduce inflammation in mouse articular chondrocytes stimulated with interleukin-1β [J].

Campo, Giuseppe M. ;

Avenoso, Angela ;

D'Ascola, Angela ;

Scuruchi, Michele ;

Prestipino, Vera ;

Nastasi, Giancarlo ;

Calatroni, Alberto ;

Campo, Salvatore .

FEBS JOURNAL, 2012, 279 (12) :2120-2133

[7]

CHONDRO-OSSEOUS DYSPLASIA OF ADENOSINE-DEAMINASE DEFICIENCY WITH SEVERE COMBINED IMMUNODEFICIENCY [J].

CEDERBAUM, SD ;

KAITILA, I ;

RIMOIN, DL ;

STIEHM, ER .

JOURNAL OF PEDIATRICS, 1976, 89 (05) :737-742

[8]

Purinergic regulation of the immune system [J].

Cekic, Caglar ;

Linden, Joel .

NATURE REVIEWS IMMUNOLOGY, 2016, 16 (03) :177-192

[9]

Concise review: Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing [J].

Chamberlain, Giselle ;

Fox, James ;

Ashton, Brian ;

Middleton, Jim .

STEM CELLS, 2007, 25 (11) :2739-2749

[10]

Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression [J].

Corciulo, Carmen ;

Lendhey, Matin ;

Wilder, Tuere ;

Schoen, Hanna ;

Cornelissen, Alexander Samuel ;

Chang, Gregory ;

Kennedy, Oran D. ;

Cronstein, Bruce N. .

NATURE COMMUNICATIONS, 2017, 8

← 1 2 3 4 5 6 →