Complexities of oestrogen in stroke

被引：21

作者：

Carswell, Hilary V. O. ^{[1
]}

Macrae, I. Mhairi ^{[2
]}

Farr, Tracy D. ^{[2
]}

机构：

[1] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NR, Lanark, Scotland

[2] Univ Glasgow, Div Clin Neurosci, Wellcome Surg Inst, Glasgow G61 1QH, Lanark, Scotland

来源：

CLINICAL SCIENCE | 2010年 / 118卷 / 5-6期

关键词：

cardiovascular disease; cerebrovascular system; hormone-replacement therapy; oestrogen; selective oestrogen receptor modulator (SERM); stroke; HORMONE REPLACEMENT THERAPY; MIDDLE CEREBRAL-ARTERY; HEALTH INITIATIVE MEMORY; DENDRITIC SPINE DENSITY; ISCHEMIC BRAIN-INJURY; ESTRADIOL-MEDIATED PROTECTION; CONJUGATED EQUINE ESTROGENS; MILD COGNITIVE IMPAIRMENT; CORONARY-HEART-DISEASE; PROGRAMMED CELL-DEATH;

D O I：

10.1042/CS20090018

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Evidence exists for the potential protective effects of circulating ovarian hormones in stroke, and oestrogen reduces brain damage in animal ischaemia models. However, a recent clinical trial indicated that HRT (hormone-replacement therapy) increased the incidence of stroke in postmenopausal women, and detrimental effects of oestrogen on stroke outcome have been identified in a meta-analysis of HRT trials and in pre-clinical research studies. Therefore oestrogen is not an agent that can be promoted as a potential stroke therapy. Many published reviews have reported the neuroprotective effects of oestrogen in stroke, but have failed to include information on the detrimental effects. This issue is addressed in the present review, along with potential mechanisms of action, and the translational capacity of pre-clinical research.

引用

页码：375 / 389

页数：15

共 178 条

[1]

Gender-linked brain injury in experimental stroke [J].

Alkayed, NJ ;

Harukuni, I ;

Kimes, AS ;

London, ED ;

Traystman, RJ ;

Hurn, PD .

STROKE, 1998, 29 (01) :159-165

[2]

Neuroprotective effects of female gonadal steroids in reproductively senescent female rats [J].

Alkayed, NJ ;

Murphy, SJ ;

Traystman, RJ ;

Hurn, PD .

STROKE, 2000, 31 (01) :161-167

[3]

Effects of conjugated, equine estrogen in postmenopausal women with hysterectomy - The women's health initiative randomized controlled trial [J].

Anderson, GL ;

Limacher, M ;

Assaf, AR ;

Bassford, T ;

Beresford, SAA ;

Black, H ;

Bonds, D ;

Brunner, R ;

Brzyski, R ;

Caan, B ;

Chlebowski, R ;

Curb, D ;

Gass, M ;

Hays, J ;

Heiss, G ;

Hendrix, S ;

Howard, BV ;

Hsia, J ;

Hubbell, A ;

Jackson, R ;

Johnson, KC ;

Judd, H ;

Kotchen, JM ;

Kuller, L ;

LaCroix, AZ ;

Lane, D ;

Langer, RD ;

Lasser, N ;

Lewis, CE ;

Manson, J ;

Margolis, K ;

Ockene, J ;

O'Sullivan, MJ ;

Phillips, L ;

Prentice, RL ;

Ritenbaugh, C ;

Robbins, J ;

Rossouw, JE ;

Sarto, G ;

Stefanick, ML ;

Van Horn, L ;

Wactawski-Wende, J ;

Wallace, R ;

Wassertheil-Smoller, S .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (14) :1701-1712

[4]

Effect of oral postmenopausal hormone replacement on progression of atherosclerosis -: A randomized, controlled trial [J].

Angerer, P ;

Störk, S ;

Kothny, W ;

Schmitt, P ;

von Schacky, C .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (02) :262-268

[5]

17β-estradiol pretreatment reduces bleeding and brain injury after intracerebral hemorrhagic stroke in male rats [J].

Auriat, A ;

Plahta, WC ;

McGie, SC ;

Yan, R ;

Colbourne, F .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (02) :247-256

[6]

Mechanisms involved in the protective effect of estradiol-17β on lipid peroxidation and DNA damage [J].

Ayres, S ;

Abplanalp, W ;

Liu, JH ;

Subbiah, MTR .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1998, 274 (06) :E1002-E1008

[7]

Risk-benefit profile for raloxifene: 4-year data from the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial [J].

Barrett-Connor, E ;

Cauley, JA ;

Kulkarni, PM ;

Sashegyi, A ;

Cox, DA ;

Geiger, MJ .

JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (08) :1270-1275

[8]

Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women [J].

Barrett-Connor, Elizabeth ;

Mosca, Lori ;

Collins, Peter ;

Geiger, Mary Jane ;

Grady, Deborah ;

Kornitzer, Marcel ;

McNabb, Michelle A. ;

Wenger, Nanette K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (02) :125-137

[9]

ESTROGEN AND CORONARY HEART-DISEASE IN WOMEN [J].

BARRETTCONNOR, E ;

BUSH, TL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 265 (14) :1861-1867

[10]

Association between hormone replacement therapy and subsequent stroke: a meta-analysis [J].

Bath, PMW ;

Gray, LJ .

BRITISH MEDICAL JOURNAL, 2005, 330 (7487) :342-344A

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