A Phase III Randomized Trial of Lobectomy Versus Limited Resection for Small-sized Peripheral Non-small Cell Lung Cancer (JCOG0802/WJOG4607L)

被引：460

作者：

Nakamura, Kenichi ^{[2
]}

Saji, Hisashi ^{[3
]}

Nakajima, Ryu ^{[4
]}

Okada, Morihito ^{[5
]}

Asamura, Hisao ^{[6
]}

Shibata, Taro ^{[2
]}

Nakamura, Shinichiro ^{[7
]}

Tada, Hirohito ^{[4
]}

Tsuboi, Masahiro ^{[1
]}

机构：

[1] Kanagawa Canc Ctr, Dept Thorac Surg, Asahi Ku, Yokohama, Kanagawa 2410815, Japan

[2] Natl Canc Ctr, Ctr Canc Control & Informat Serv, Clin Trials & Practice Support Div, Tokyo 104, Japan

[3] Tokyo Med Univ Hosp, Dept Thorac Surg, Tokyo, Japan

[4] Osaka City Gen Med Ctr, Dept Thorac Surg, Osaka, Japan

[5] Hiroshima Univ Hosp, Dept Thorac Surg, Hiroshima, Japan

[6] Natl Canc Ctr, Dept Thorac Surg, Tokyo, Japan

[7] W Japan Oncol Grp Data Ctr, Yokohama, Kanagawa, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2010年 / 40卷 / 03期

关键词：

non-small cell lung carcinoma; thoracic surgery; pneumonectomy; clinical trial; Phase III;

D O I：

10.1093/jjco/hyp156

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A Phase III study was started in Japan to evaluate the non-inferiority in overall survival of segmentectomy compared with lobectomy in patients with small-sized (diameter < 2 cm) peripheral non-small cell lung cancer, excluding radiologically determined non-invasive cancer. This study began in August 2009, and a total of 1100 patients will be accrued from 71 institutions within 3 years. The primary endpoint is overall survival. The secondary endpoints are post-operative respiratory function, relapse-free survival, proportion of local recurrence, adverse events, proportion of patients who complete segmentectomy, duration of hospitalization, duration of chest tube placement, operation time, blood loss and number of auto-sutures used. This study is one of the first intergroup studies in Japan between the Japan Clinical Oncology Group and the West Japan Oncology Group.

引用

页码：271 / 274

页数：4

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