Efficient and versatile synthesis of A-ring precursors of 1 alpha,25-dihydroxy-vitamin D-3 and analogues. Application to the synthesis of Lythgoe-Roche phosphine oxide.

被引：56

作者：

Mourino, A ^{[1
]}

Torneiro, M ^{[1
]}

Vitale, C ^{[1
]}

Fernandez, S ^{[1
]}

PerezSestelo, J ^{[1
]}

Anne, S ^{[1
]}

Gregorio, C ^{[1
]}

机构：

[1] UNIV SANTIAGO DE COMPOSTELA,FAC QUIM,CSIC,UNIDAD ASOC,E-15706 SANTIAGO COMPOSTE,SPAIN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(97)01005-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, versatile synthesis of Lythgoe-Phosphine Oxide has been developed starting from l-carvone. The key steps are rupture of protected epoxide 7 to give dicarbonyl compound 8, preparation of vinylic triflate 2, and palladium-catalysed cyclization-carbonylation of vinylic triflate 2. (C) 1997 Elsevier Science Ltd.

引用

页码：4713 / 4716

页数：4

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