Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC

被引：106

作者：

Schmitz, FJ

Jones, ME

Hofmann, B

Hansen, B

Scheuring, S

Lückefahr, M

Fluit, A

Verhoef, J

Hadding, U

Heinz, HP

Köhrer, K

机构：

[1] Univ Dusseldorf, Inst Med Microbiol & Virol, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Mol Biol Zentrallabor, Biol Med Forschungszentrum, D-40225 Dusseldorf, Germany

[3] Univ Utrecht, Eijkman Winkler Inst Med Microbiol, Utrecht, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 05期

关键词：

D O I：

10.1128/AAC.42.5.1249

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

One hundred sixteen unrelated clinical isolates of Staphylococcus aureus (70 ciprofloxacin resistant and 46 ciprofloxacin susceptible) from eight countries were studied for the presence of mutations in the grlA, grlB, gyrA, and gyrB gene loci. Two mutations within grlA (located at codons 80 and 84) and two mutations within gyrA (located at codons 84 and 88) were clearly associated with ciprofloxacin resistance, although other mutations detected within the four genes studied may also contribute to decreased susceptibility.

引用

收藏

页码：1249 / 1252

页数：4

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