An efficient catalytic enantioselective fluorination of β-ketophosphonates using chiral palladium complexes

被引：95

作者：

Hamashima, Y

Suzuki, T

Shimura, Y

Shimizu, T

Umebayashi, N

Tamura, T

Sasamoto, N

Sodeoka, M ^{[1
]}

机构：

[1] Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Aoba Ku, Sendai, Miyagi 9808577, Japan

[2] RIKEN, Wako, Saitama 3510198, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 09期

基金：

日本学术振兴会;

关键词：

Pd complex; fluorination; beta-ketophosphonate; asymmetric catalysis;

D O I：

10.1016/j.tetlet.2005.01.018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

On the basis of our Pd enolate chemistry, we have succeeded in developing an efficient catalytic enantioselective fluorination of beta-ketophosphonates. In the presence of chiral Pd complexes 1 (1-10 mol %), various substrates including cyclic and acyclic beta-ketophosphonates underwent the reaction with N-fluorobenzenesulfonimide (NFS1) in EtOH to give the corresponding fluorinated products in a highly enantioselective manner (94-98% ee). (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1447 / 1450

页数：4

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