A functional human IgM response to HIV-1 Env after immunization with NYVAC HIVC

被引：9

作者：

Sheppard, Neil C. ^{[1
]}

Bates, Anna C. ^{[1
]}

Sattentau, Quentin J. ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

AIDS | 2007年 / 21卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1097/QAD.0b013e32803277f9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Env-specific IgG and IgM were detected in 25 and 60%, respectively, of volunteers immunized with NYVAC expressing clade C gp120. The serum sample with the highest IgM titre but undetectable IgG neutralized the homologous isolate with a reciprocal IC90 titre of 7.8 in the absence of complement, and 24.4 in the presence of complement (P=0.0003). These results suggest that vaccine-induced, Env-specific IgM may have antiviral activity and should be subjected to further investigation.

引用

页码：524 / 527

页数：4

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