Nicotinic α7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage

被引：125

作者：

Shimohama, S

Greenwald, DL

Shafron, DH

Akaika, A

Maeda, T

Kaneko, S

Kimura, J

Simpkins, CE

Day, AL

Meyer, EM

机构：

[1] Univ Florida, J Hillis Miller Hlth Ctr, Coll Med, Dept Pharmacol, Gainesville, FL 32610 USA

[2] Kyoto Univ, Fac Med, Dept Neurol, Kyoto 606, Japan

[3] Univ Florida, Coll Med, Dept Neurosurg, Gainesville, FL 32610 USA

[4] Kyoto Univ, Fac Pharmaceut Sci, Dept Pharmacol, Kyoto 606, Japan

来源：

BRAIN RESEARCH | 1998年 / 779卷 / 1-2期

关键词：

DMXB; NMDA receptor; neuroprotection; nicotinic; ischemia; mecamylamine;

D O I：

10.1016/S0006-8993(97)00194-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The alpha 7 receptor agonist dimethoxybenzylidene anabaseine (DMXB) protected rat neocortical neurons against excitotoxicity administered 24 h before, but not concomitantly with, NMDA. This action was blocked by nicotinic but not muscarinic antagonists. DMXB (1 mg/kg i.p.) also reduced infarct size in rats when injected 24 h before, but not during, focal ischemic insults. In a mecamylamine-sensitive manner, alpha 7 receptors appear neuroprotective in non-apoptotic model. (C) 1998 Elsevier Science B.V.

引用

页码：359 / 363

页数：5

共 13 条

[1] NICOTINE-INDUCED PROTECTION OF CULTURED CORTICAL-NEURONS AGAINST N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED GLUTAMATE CYTOTOXICITY [J].