Silicone resin derived larnite/C scaffolds via 3D printing for potential tumor therapy and bone regeneration

被引：66

作者：

Fu, Shengyang ^{[1
,2
]}

Hu, Haoran ^{[3
]}

Chen, Jiajie ^{[1
]}

Zhu, Yufang ^{[1
,2
]}

Zhao, Shichang ^{[3
]}

机构：

[1] Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, 516 Jungong Rd, Shanghai 200093, Peoples R China

[2] Huanggang Normal Univ, Coll Chem Engn, Hubei Key Lab Proc & Applicat Catalyt Mat, Huanggang City 438000, Hubei, Peoples R China

[3] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Orthoped, 600 Yishan Rd, Shanghai 200233, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2020年 / 382卷

基金：

中国国家自然科学基金;

关键词：

Scaffolds; Polymer-derived bioceramics; 3D printing; Tumor therapy; Bone regeneration; IN-VITRO BIOACTIVITY; CARBON DOTS; DICALCIUM SILICATE; CERAMIC SCAFFOLDS; BETA-CA2SIO4; SCAFFOLDS; PHOTOTHERMAL THERAPY; COMPOSITE SCAFFOLDS; NANOPARTICLES; DIFFERENTIATION; BIOMATERIALS;

D O I：

10.1016/j.cej.2019.122928

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

Three dimensional (3D) printing has been used to fabricate bioceramic scaffolds for treating the tumor-related defects in recent years, but the fabrication process and the introduction of anti-tumor agents are still challenging. In this study, porous free carbon-embedding larnite (larnite/C) scaffolds have been successfully fabricated by 3D printing of the silicone resin loaded with CaCO3 filler and high temperature treatment under an inert atmosphere. The fabricated larnite/C scaffolds had uniform interconnected macropores (ca. 400 mu m), and exhibited excellent photothermal effect, which was able to kill human osteosarcoma cells (MNNG/HOS) and inhibit the tumor growth in nude mice. Moreover, the larnite/C scaffolds could stimulate the expression of osteogenesis-related gene (ALP, OCN and Runx-2) in rat bone mesenchymal stem cells (rBMSCs), and also promoted new bone formation in critical-sized rat calvarial defects. Therefore, the combination of 3D printing with polymer-derived ceramics strategy could fabricate multifunctional bioceramic scaffolds, which would be promising for potential application in treating tumor-related bone defects.

引用

页数：11

共 52 条

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