New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals

被引：494

作者：

Hinuma, S

Shintani, Y

Fukusumi, S

Iijima, N

Matsumoto, Y

Hosoya, M

Fujii, R

Watanabe, T

Kikuchi, K

Terao, Y

Yano, T

Yamamoto, T

Kawamata, Y

Habata, Y

Asada, M

Kitada, C

Kurokawa, T

Onda, H

Nishimura, O

Tanaka, M

Ibata, Y

Fujino, M

机构：

[1] Takeda Chem Ind Ltd, Pharmaceut Discovery Res Div, Tsukuba, Ibaraki 3004293, Japan

[2] Kyoto Prefectural Univ Med, Dept Anat & Neurobiol, Kamikyo Ku, Kyoto 6020841, Japan

[3] Kyoto Prefectural Univ Med, Dept Neurol, Kamikyo Ku, Kyoto 6020841, Japan

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 10期

关键词：

D O I：

10.1038/35036326

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, 0T7T022, specifically respond to synthetic hRFRP-1 and hRFRP-3 but not to hRFRP-2. RFRP and 0T7T022 mRNAs are expressed in particular regions of the rat hypothalamus, and intracerebroventricular administration of hRFRP-1 increases prolactin secretion in rats. Our results indicate that a variety of RFamide-related peptides may exist and function in mammals.

引用

页码：703 / 708

页数：6

共 33 条

[1] AARNISALO AA, 1997, NEUROENDOCRINOL LETT, V18, P191
[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, SF
Madden, TL
Schaffer, AA
Zhang, JH
Zhang, Z
Miller, W
Lipman, DJ
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (17) : 3389 - 3402
[3] Parasitic peptides! The structure and function of neuropeptides in parasitic worms
Day, TA
Maule, AG
[J]. PEPTIDES, 1999, 20 (08) : 999 - 1019
[4] A NOVEL ACTIVE PENTAPEPTIDE FROM CHICKEN BRAIN IDENTIFIED BY ANTIBODIES TO FMRFAMIDE
DOCKRAY, GJ
REEVE, JR
SHIVELY, J
GAYTON, RJ
BARNARD, CS
[J]. NATURE, 1983, 305 (5932) : 328 - 330
[5] PROLACTIN
FRANTZ, AG
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1978, 298 (04) : 201 - 207
[6] Isolation and characterization of a novel bioactive peptide, Carassius RFamide (C-RFa), from the brain of the Japanese crucian carp
Fujimoto, M
Takeshita, K
Wang, XY
Takabatake, I
Fujisawa, Y
Teranishi, H
Ohtani, M
Muneoka, Y
Ohta, S
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 242 (02) : 436 - 440
[7] Identification and characterization of a novel human cortistatin-like peptide
Fukusumi, S
Kitada, C
Takekawa, S
Sakamoto, J
Miyamoto, M
Hinuma, S
Kitano, K
Fujino, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 232 (01) : 157 - 163
[8] FUXE K, 1964, Z ZELLFORSCH MIK ANA, V61, P710
[9] CONFORMATIONAL STUDIES ON THE PANCREATIC-POLYPEPTIDE HORMONE FAMILY
GLOVER, ID
BARLOW, DJ
PITTS, JE
WOOD, SP
TICKLE, IJ
BLUNDELL, TL
TATEMOTO, K
KIMMEL, JR
WOLLMER, A
STRASSBURGER, W
ZHANG, YS
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1984, 142 (02): : 379 - 385
[10] The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors
Hinuma, S
Onda, H
Fujino, M
[J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 1999, 77 (06): : 495 - 504

← 1 2 3 4 →