Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia

被引:117
作者
Calabresi, P
Cupini, LM
Centonze, D
Pisani, F
Bernardi, G
机构
[1] Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy
[2] Univ Messina, Dipartimento Neurosci Psichiatria & Anastesiol, Messina, Italy
[3] Fdn S Lucia, Ist Ric & Cura Carattere Sci, Rome, Italy
关键词
D O I
10.1002/ana.10603
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Several new antiepileptic drugs (AEDs) have been introduced for clinical use recently. These new AEDs, as did the classic AEDs, target multiple cellular sites both pre- and postsynaptically. The major common. goal of the pharmacological treatment using AEDs is to counteract abnormal brain excitability by either decreasing excitatory transmission or enhancing neuronal inhibition. Interestingly, an excessive release of excitatory amino acids and a reduced neuronal inhibition also occur in brain ischemia. Thus, recently, the use of AEDs as a possible neuroprotective strategy in brain ischemia. is receiving increasing attention, and many AEDs have been tested in animal models of stroke, providing encouraging results. Experimental studies utilizing global or focal ischemia. in rodents have provided insights into the possible neuroprotective action of the various AEDs. However, the implication of these studies in the treatment of acute stroke in humans is not always direct. In fact, various clinical studies with drugs targeting the same voltage- and ligand-gated channels modulated by most of the AEDs failed to show neuroprotection. The differential mechanisms that underlie the development of focal ischemic injury in experimental animal models versus human stroke require further investigation to open a new therapeutic perspective for neuroprotection that might be applicable in the future.
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收藏
页码:693 / 702
页数:10
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