Chronic stress and social housing differentially affect neurogenesis in male and female rats

被引:188
作者
Westenbroek, C
Den Boer, JA
Veenhuis, M
Ter Horst, GJ
机构
[1] Univ Groningen, Grad Sch Behav & Cognit Neurosci, Dept Psychiat, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, NL-9700 RB Groningen, Netherlands
关键词
gender; BrdU; hippocampus; affective disorders; social support;
D O I
10.1016/j.brainresbull.2004.08.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Stress plays an important role in the development of affective disorders. Women show a higher prevalence for these disorders than men. The course of a depression is thought to be positively influenced by social support. We have used a chronic stress model in which rats received foot-shocks daily for 3 weeks. Since rats are social animals we hypothesised that 'social support' might reduce the adverse effects of chronic stress. To test this hypothesis, male and female rats were housed individually or socially in unisex groups of four rats. The proliferation marker bromodeoxyuridine (BrdU) was injected 2 weeks before the sacrifice to investigate if stress and social housing influenced the survival of proliferating cells in the dentate gyrus (DG). To investigate changes in proliferation, another group of rats was sacrificed the day after the last BrdU injection. Stress significantly decreased BrdU labelling in individually housed males and not significantly in socially housed males. In individually housed females stress increased BrdU labelling, which was prevented by social housing. The increase found in females is most likely caused by differences in survival rate, since cell proliferation was not affected by stress or housing conditions. These results indicate that social support can affect neurogenesis in both female and male rats, however in a different way. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:303 / 308
页数:6
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