Progression of chronic renal failure in focal segmental glomerulosclerosis: consequence of podocyte damage or of tubulointerstitial fibrosis?

被引：24

作者：

Kriz, W ^{[1
]}

机构：

[1] Inst Anat & Zellbiol 1, D-69120 Heidelberg, Germany

来源：

PEDIATRIC NEPHROLOGY | 2003年 / 18卷 / 07期

关键词：

pathway to nephron degeneration; protein leakage as an effector of progression; atubular glomeruli; beneficial effects of ACE inhibitors;

D O I：

10.1007/s00467-003-1172-7

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The decline in renal function in chronic renal failure is based on the progressive loss of viable nephrons. The pathways to nephron loss in conjunction with chronic renal disease generally start in the glomerulus, extending onto the tubulointerstitium via the urinary pole. Pathways to nephron degeneration starting focally in the tubulointerstitium have yet to be described. The deleterious effects of protein leakage on progression appear to be a result of podocyte damage, the beneficial effects of ACE inhibitors a result of podocyte protection.

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收藏

页码：617 / 622

页数：6

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