Pharmacogenomics and serotonergic agents: research observations and potential clinical practice implications

被引：8

作者：

Camilleri, M. ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, CENTER Program, Rochester, MN 55905 USA

来源：

NEUROGASTROENTEROLOGY AND MOTILITY | 2007年 / 19卷

关键词：

alosertron; CYP450; irritable bowel; pharmacogenomics; serotonin; tegaserod;

D O I：

10.1111/j.1365-2982.2007.00961.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pharmacogenomics of serotonin are potentially relevant in research and clinical practice. There are few proven examples of the importance of pharmacogenetics of serotonin-modifying agents used in functional gastrointestinal or motility disorders. Drug metabolism is dependent on function of the cytochrome P450 enzymes, such as 2D6 and 3A4. Genetic variations in transporters and translation mechanisms have been associated with responses to treatment in irritable bowel syndrome and in obesity. Research on the impact of polymorphisms of key proteins on the pharmacokinetics and pharmacodynamics of drugs that alter serotonin-mediated signalling will assist in explaining diverse responses to those drugs and ultimately improve clinical practice, individualizing medicine.

引用

页码：40 / 45

页数：6

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