Synthesis of (±)-7-(3,4,5-trimethoxyphenyl)-7-deoxyidarubicinone.: A new family of anthracycline analogues

被引：4

作者：

Caballero, E ^{[1
]}

Medarde, M ^{[1
]}

de Clairac, RPL ^{[1
]}

Sahagún, H ^{[1
]}

Tomé, F ^{[1
]}

机构：

[1] Univ Salamanca, Fac Farm, Dept Quim Organ & Farmaceut, E-37007 Salamanca, Spain

来源：

TETRAHEDRON | 1998年 / 54卷 / 22期

关键词：

D O I：

10.1016/S0040-4020(98)00304-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the first representative compound of 7-aryl anthracycline analogues, is described. 1-Alkyl-3-trialkylsiloxydienes, prepared from readily available materials, are transformed through a Diels-Alder cycloaddition into a tetracyclic ketone, that is converted into (+/-)-7-(3,4,5-trimethoxyphenyl)-7-deoxyidarubicinone. The conformations of the target compound and intermediate products are studied. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

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页码：6111 / 6122

页数：12

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