Can combined T-cell- and antibody-based immunotherapy outsmart tumor cells?

被引：38

作者：

Abken, H ^{[1
]}

Hombach, A

Reinhold, U

Ferrone, S

机构：

[1] Univ Cologne, Dept Internal Med 1, Lab Tumor Genet, D-50924 Cologne, Germany

[2] Univ Homburg, Dept Dermatol, D-66421 Homburg, Germany

[3] New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 01期

关键词：

D O I：

10.1016/S0167-5699(97)01191-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Advantages of T-cell- and antibody-based immunotherapy can be combined by grafting cytotoxic T lymphocytes with chimeric receptors composed of antibody fragments (which recognize tumor-cell antigen) and a cellular activation motif. Here, Hinrich Abken and colleagues discuss the potential of this approach for immunotherapy of malignant diseases.

引用

页码：2 / 5

页数：6

共 25 条

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