The quest for a vascular endothelial cannabinoid receptor

被引：37

作者：

Kunos, G ^{[1
]}

Bátkai, S ^{[1
]}

Offertáler, L ^{[1
]}

Mo, F ^{[1
]}

Liu, J ^{[1
]}

Karcher, J ^{[1
]}

Harvey-White, J ^{[1
]}

机构：

[1] NIAAA, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2002年 / 121卷 / 1-2期

关键词：

endocannabinoids; hypotension; vasorelaxation; G proteins; endothelium; mesenterium;

D O I：

10.1016/S0009-3084(02)00145-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review examines pharmacological and biochemical evidence that suggests the existence of an as yet undefined endothelial receptor that mediates endocannabinoid-induced vasodilation. The signaling mechanisms triggered through this receptor and its potential physiological role are also discussed. Since vasodilation is often associated with hypotension, mechanisms involved in the hypotensive actions of cannabinoids, including the endocannabinoids anandamide and 2-arachidonoylglycerol, are also briefly reviewed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：45 / 56

页数：12

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