Acute megakaryocytic leukaemia with acquired polysomy 21 and translocation t(1;21)

被引：3

作者：

Paulien, S

Busson-Le Coniat, M

Berger, R

机构：

[1] Inst Genet Mol Paris, Inserm U434, F-75010 Paris, France

[2] Inst Genet Mol Paris, CNRS SDI 401 434, F-75010 Paris, France

[3] Univ Caen, IBBA, F-14032 Caen, France

来源：

ANNALES DE GENETIQUE | 2000年 / 43卷 / 02期

关键词：

acute megakaryocytic leukaemia; trisomy; 21; t(1; 21); FISH;

D O I：

10.1016/S0003-3995(00)01019-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cytogenetic study of a young child with acute megakaryocytic leukaemia (AML-M7) has shown a karyotype with 49-50 chromosomes with one and two acquired extra chromosomes 21. Fluorescence in situ hybridization detected a minor clone with translocation t(1;21) and loss of a part of chromosome band 1p36. Trisomy and polysomy 21 are not uncommon in AML-M7. A more systematic search for chromosome 21 rearrangements in AML-M7 using FISH techniques is proposed. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：99 / 104

页数：6

共 36 条

[1] GENOTYPIC AND CYTOGENETIC STUDY OF ACUTE MYELOCYTIC-LEUKEMIA AND CHRONIC MYELOCYTIC-LEUKEMIA IN BLAST CRISIS - SPECIFIC DELTA REARRANGEMENT PATTERN DOES NOT INVOLVE J-DELTA GENE LOCUS [J].