Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women

被引:76
作者
DeSouza, CA
Jones, PP
Seals, DR
机构
[1] Univ Colorado, Dept Kinesiol, Ctr Phys Activ Dis Prevent & Aging, Human Cardiovasc Res Lab, Boulder, CO 80309 USA
[2] Univ Colorado, Hlth Sci Ctr, Dept Med, Div Cardiol, Denver, CO USA
[3] Univ Colorado, Hlth Sci Ctr, Dept Med, Div Geriatr Med, Denver, CO USA
关键词
aging; exercise; fibrinogen; fibrinolytic system; fibrin D-dimer;
D O I
10.1161/01.ATV.18.3.362
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adverse changes in coagulation and fibrinolytic factors are thought to contribute to the increased risk of cardiovascular disease and atherothrombosis with age. We tested the hypothesis that such age-related changes in specific coagulation and fibrinolytic factors are absent in physically active women. Resting levels of plasma fibrinogen, tissue-type plasminogen activator (t-PA) antigen and activity, plasminogen activator inhibitor-1 (PAI-1) antigen and activity, and fibrin D-dimer were measured in 24 healthy premenopausal women: 11 sedentary (aged 28+/-1 years; Pre-S) and 13 physically active (aged 30+/-1 years; Pre-PA) and in 27 healthy postmenopausal women: 14 sedentary (aged 61+/-1 years; Post-S) and 13 physically active (aged 58+/-1 years; Post-PA). Post-S had higher (P<.05) fibrinogen, t-PA antigen, PAI-1 antigen, PAI-1 activity, and fibrin D-dimer levels and lower t-PA activity than Pre-S. Post-PA demonstrated lower (P<.01) plasma fibrinogen, t-PA antigen, PAI-1 antigen, and PAI-1 activity and higher (P<.01) t-PA activity levels than Post-S. In addition, plasma fibrin D-dimer levels tended (P=.06) to be lower in Post-PA than in Post-S. Although plasma levels of fibrinogen and fibrin D-dimer in Post-PA were lower than in Post-S, they were higher (P<.05) than in Pre-PA. Importantly, however, the fibrinolytic profile of Post-PA did not differ from that of Pre-PA. The results of the present study demonstrate that the adverse age-associated differences in plasma fibrinogen concentrations and the endogenous fibrinolytic system in sedentary healthy women are either attenuated or absent in highly physically active women. The smaller or absent age-related differences in coagulation and fibrinolytic factors in women who habitually exercise may represent an important mechanism contributing to their lower age-related increase in both cardiovascular disease and atherothrombotic events. Future studies need to determine whether women who are moderately active would demonstrate the same favorable hemostatic profile.
引用
收藏
页码:362 / 368
页数:7
相关论文
共 49 条
[1]  
*AM HEART ASS, 1996, HEART STROK FACTS 19
[2]   COAGULATION, FIBRINOLYSIS AND HEMORHEOLOGY IN PREMENOPAUSAL OBESE WOMEN WITH DIFFERENT BODY-FAT DISTRIBUTION [J].
AVELLONE, G ;
DIGARBO, V ;
CORDOVA, R ;
RANELI, G ;
DESIMONE, R ;
BOMPIANI, GD .
THROMBOSIS RESEARCH, 1994, 75 (03) :223-231
[3]  
BORG G, 1970, Scandinavian Journal of Rehabilitation Medicine, V2, P92
[4]   DENSITOMETRIC ANALYSIS OF BODY COMPOSITION REVISION OF SOME QUANTIATIVE ASSUMPTIONS [J].
BROZEK, J ;
ANDERSON, JT ;
KEYS, A ;
GRANDE, F .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1963, 110 (01) :113-&
[5]   FIBRINOLYTIC RESPONSE DURING EXERCISE AND EPINEPHRINE INFUSION IN THE SAME SUBJECTS [J].
CHANDLER, WL ;
VEITH, RC ;
FELLINGHAM, GW ;
LEVY, WC ;
SCHWARTZ, RS ;
CERQUEIRA, MD ;
KAHN, SE ;
LARSON, VG ;
CAIN, KC ;
BEARD, JC ;
ABRASS, IB ;
STRATTON, JR .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1992, 19 (07) :1412-1420
[6]  
CHANDLER WL, 1990, BLOOD, V76, P930
[7]   ACUTE PHASE REACTION, FIBRINOGEN LEVEL AND THROMBUS SIZE [J].
CHOOI, CC ;
GALLUS, AS .
THROMBOSIS RESEARCH, 1989, 53 (05) :493-501
[8]  
CLAUSS A., 1957, ACTA HAEMATOL, V17, P237
[9]   INCREASED FIBRIN TURNOVER AND HIGH PAI-1 ACTIVITY AS PREDICTORS OF ISCHEMIC EVENTS IN ATHEROSCLEROTIC PATIENTS - A CASE-CONTROL STUDY [J].
CORTELLARO, M ;
COFRANCESCO, E ;
BOSCHETTI, C ;
MUSSONI, L ;
DONATI, MB ;
CARDILLO, M ;
CATALANO, M ;
GABRIELLI, L ;
LOMBARDI, B ;
SPECCHIA, G ;
TAVAZZI, L ;
TREMOLI, E ;
POZZOLI, E ;
TURRI, M ;
CORTELLARO, M ;
COFRANCESCO, E ;
BOSCHETTI, C ;
CARDILLO, M ;
TORRI, M ;
RAINISIO, M ;
GENTILE, G ;
MOREO, G ;
BIANCHI, O ;
LEONARDI, P ;
COLOMBI, M ;
CATALANO, M ;
GALIMBERTI, P ;
RUSSO, U ;
CRESSOTTI, A ;
CARZANIGA, G ;
NOBILI, S ;
NINNO, D ;
DONATI, MB ;
IACOVIELLO, L ;
DEGAETANO, G ;
GABRIELLI, L ;
MARTELLI, E ;
CORSI, G ;
LORENZI, G ;
LOMBARDI, B ;
CARRIERO, MR ;
COLOMBO, R ;
SPECCHIA, G ;
CIOFFI, P ;
SCIRE, A ;
TAVAZZI, L ;
GIANNUZZI, P ;
CORRA, U ;
TEMPORELLI, L ;
MORA, F .
ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (10) :1412-1417
[10]  
DESOUZA CA, 1997, J GERONTOL A-BIOL, V52, pM284