Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions

被引:75
作者
Aoki, Y
Yarchoan, R
Braun, J
Iwamoto, A
Tosato, G
机构
[1] NCI, Med Branch, NIH, Bethesda, MD 20892 USA
[2] NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA
[3] St Vincents Hosp & Med Ctr, Dept Med, New York, NY 10011 USA
[4] Univ Tokyo, Inst Med Sci, Dept Infect Dis, Tokyo, Japan
关键词
D O I
10.1182/blood.V96.4.1599.h8001599_1599_1601
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Kaposi sarcoma-associated herpesvirus encodes Viral IL-6 (vIL-6). To investigate the potential role of vIL-6 in the pathogenesis of human immunodeficiency virus (HIV)related primary effusion lymphomas (PEL), a sensitive enzyme-linked immunosorbent assay was developed for vIL-6 and applied to the study of PEL. Whereas vIL-6 was detectable in 6 of 8 PEL effusions (range, 1390-66 630 pg/mL), it was not detectable in any of the control effusions, As expected, all PEL effusions contained human IL-6 (range, 957-37 494 pg/mL), and 7 of 8 contained detectable human IL-10 (range, 66-2,521,297 pg/mL), Human and vIL-6 have previously been shown to induce vascular endothelial growth factor, which in turn can increase vascular permeability. The results of the current study suggest that these cytokines play a central role in the pathogenesis and manifestations of PEL. (Blood. 2000;96: 1599-1601) (C) 2000 by The American Society of Hematology.
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页码:1599 / 1601
页数:3
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