In vitro effect of glucocorticoids on phagocytic function of sheep alveolar macrophages

被引：14

作者：

Belayat, F

Meniai, K

Michaux, C

Kafidi, N

Coignoul, F

Dewaele, A

机构：

[1] Univ Liege, Fac Vet Med, Dept Pathol, Serv Pathol Gen, B-4000 Liege, Belgium

[2] Univ Liege, Fac Vet Med, Serv Med Interne Grands Anim, B-4000 Liege, Belgium

[3] Univ Liege, Fac Vet Med, Serv Genet, B-4000 Liege, Belgium

来源：

VETERINARY JOURNAL | 1998年 / 155卷 / 02期

关键词：

sheep; cellular immunity; alveolar macrophage; phagocytosis; glucocorticoids;

D O I：

10.1016/S1090-0233(98)80015-4

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The potentiation of infection is a recognized adverse effect of steroids. This study examined the in vitro effect of glucocorticoids on sheep alveolar macrophage phagocytic function, an essential means of cellular defence in the lungs, by evaluating the phagocytosis of zymosan particles after 30 min of contact between alveolar macrophages and steroids. Hydrocortisone, dexamethasone phosphate and methylprednisolone significantly reduced the phagocytic capability of sheep alveolar macrophages, but the effects of dexamethasone isonicotinate, prednisolone and flumethasone were less marked.

引用

页码：177 / 181

页数：5

共 25 条

[1] SIMULTANEOUS DETERMINATION OF CORTICOSTERONE, HYDROCORTISONE, AND DEXAMETHASONE IN DOG PLASMA USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].