Meningitis bacterium is viable without endotoxin

被引：227

作者：

Steeghs, L ^{[1
]}

den Hartog, R ^{[1
]}

den Boer, A ^{[1
]}

Zomer, B ^{[1
]}

Roholl, P ^{[1
]}

van der Ley, P ^{[1
]}

机构：

[1] RIVM, Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

来源：

NATURE | 1998年 / 392卷 / 6675期

关键词：

D O I：

10.1038/33046

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The outer membrane of Gram-negative bacteria contains lipopolysaccharide (LPS) as its outer monolayer. This is anchored to the membrane by lipid A, which is responsible for LPS's activity as an endotoxin1. In Escherichia coli, conditionally lethal mutants have been reported for the genes involved in the early steps of lipid A biosynthesis2, suggesting that this part of the LPS molecule is essential for bacterial growth. However, we have isolated a mutant of Neisseria meningitidis which is viable in spite of an early block in lipid A biosynthesis that causes a loss of endotoxin activity.

引用

页码：449 / 450

页数：2

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