Exogenous luteinizing hormone in controlled ovarian hyperstimulation for assisted reproduction techniques

被引：162

作者：

Ferraretti, AP ^{[1
]}

Gianaroli, L ^{[1
]}

Magli, MC ^{[1
]}

D'angelo, A ^{[1
]}

Farfalli, V ^{[1
]}

Montanaro, N ^{[1
]}

机构：

[1] SISMER Reprod Unit, I-40138 Bologna, Italy

来源：

FERTILITY AND STERILITY | 2004年 / 82卷 / 06期

关键词：

recombinant LH; gonadotropins; oocyte competence; IVF; ICSI; FSH hyporesponsiveness;

D O I：

10.1016/j.fertnstert.2004.06.041

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To investigate the role of exogenous LH in controlled ovarian hyperstimulation for assisted reproductive technologies. Design: Prospective randomized study. Setting: SISMER fertility unit. Patient(s): Women showing a hyporesponsiveness to FSH under GnRH agoinst down-regulation were randomized into three groups: group A (n = 54) received an increased dosage of FSH; group B (n = 54) was administered recombinant LH in addition to the increased dose of FSH; group C (n = 22) was given additional FSH and LH using hMG as a combined drug. Fifty-four age-matched women with no need to increase the FSH dose were included as a control group (D). Intervention(s): None. Main Outcome Measure(s): Implantation and live birth rate per started cycles. Result(s): In group B, the pregnancy and implantation rates were statistically higher when compared with groups A and C and did not differ from the control group for normal response. The live birth rate was similar in groups B and D but was half as high in groups A and C. Conclusion(s): Hyporesponsiveness to FSH could be related to iatrogenic LH deficiency that, in turn, could affect oocyte competence. Addition of a small amount of recombinant LH is able to rescue oocyte competence to produce viable embryos. (C) 2004 by American Society for Reproductive Medicine.

引用

页码：1521 / 1526

页数：6

共 45 条

[1] Suppression of LH during ovarian stimulation:: analysing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH [J].