Stereoselective total synthesis of (+)-artemisinin

被引：51

作者：

Yadav, JS ^{[1
]}

Babu, RS ^{[1
]}

Sabitha, G ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Oragan Chem Sci, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 02期

关键词：

artemisinin; stereoselective; iodolactone; tris(trimethylsilyl)silane;

D O I：

10.1016/S0040-4039(02)02500-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the novel antimalarial drug, a sesquiterpene endoperoxide, (+)-artemisinin is described. The approach is flexible and stereoselective. The use of an intermolecular radical reaction on an intermediate iodolactone and a Wittig reaction on a ketone were employed for the synthesis. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：387 / 389

页数：3

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