Adult mesenchymal stem cells and cell-based tissue engineering

被引：588

作者：

Tuan, RS ^{[1
]}

Boland, G ^{[1
]}

Tuli, R ^{[1
]}

机构：

[1] NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Bethesda, MD 20892 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2003年 / 5卷 / 01期

关键词：

cell differentiation; cell signaling; mesenchymal stem cells; stem cells; tissue engineering;

D O I：

10.1186/ar614

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues, including bone marrow stroma and a number of connective tissues, has provided exciting prospects for cell-based tissue engineering and regeneration. This review focuses on the biology of MSCs, including their differentiation potentials in vitro and in vivo, and the application of MSCs in tissue engineering. Our current understanding of MSCs lags behind that of other stem cell types, such as hematopoietic stem cells. Future research should aim to define the cellular and molecular fingerprints of MSCs and elucidate their endogenous role(s) in normal and abnormal tissue functions.

引用

页码：32 / 45

页数：14

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