Response of F344 rats to inhalation of subclinical levels of sarin:: exploring potential causes of Gulf War illness

被引：30

作者：

Henderson, RF

Barr, EB

Blackwell, WB

Clark, CR

Conn, CA

Kalra, R

March, TH

Sopori, ML

Tesfaigzi, Y

Ménache, MG

Mash, DC

Dokladny, K

Kozak, W

Kozak, A

Wachulec, M

Rudolph, K

Kluger, MJ

Singh, SP

Razani-Boroujerdi, S

Langley, RJ

机构：

[1] LRRI, Albuquerque, NM 87108 USA

[2] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA

[3] Univ Miami, Miami, FL 33152 USA

[4] Univ New Mexico, Albuquerque, NM 87108 USA

[5] Med Coll Georgia, Augusta, GA 30912 USA

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 2001年 / 17卷 / 5-10期

关键词：

cholinergic receptors; immne system; nerve gas; sarin;

D O I：

10.1191/0748233701th105oa

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.

引用

页码：294 / 297

页数：4

共 3 条

[1] Effects of sarin on temperature and activity of rats as a model for Gulf War Syndrome neuroregulatory functions [J].

Conn, CA ;

Dokladny, K ;

Ménache, MG ;

Barr, EB ;

Kozak, W ;

Kozak, A ;

Wachulec, M ;

Rudolph, K ;

Kluger, MJ ;

Henderson, RF .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2002, 184 (02) :77-81

[2] Response of rats to low levels of sarin [J].

Henderson, RF ;

Barr, EB ;

Blackwell, WB ;

Clark, CR ;

Conn, CA ;

Kalra, R ;

March, TH ;

Sopori, ML ;

Tesfaigzi, Y ;

Ménache, MG ;

Mash, DC .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2002, 184 (02) :67-76

[3] Subclinical doses of the nerve gas sarin impair T cell responses through the autonomic nervous system [J].

Kalra, R ;

Singh, SP ;

Razani-Boroujerdi, S ;

Langley, RJ ;

Blackwell, WB ;

Henderson, RF ;

Sopori, ML .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2002, 184 (02) :82-87

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