A putative G-protein-coupled receptor, H218, is down-regulated during the retinoic acid-induced differentiation of F9 embryonal carcinoma cells

被引：13

作者：

Li, Y

MacLennan, AJ

Rogers, MB

机构：

[1] Univ S Florida, Dept Biol, Tampa, FL 33620 USA

[2] Univ S Florida, Dept Pharmacol, Tampa, FL 33620 USA

[3] Univ S Florida, Inst Biomol Sci, Tampa, FL 33620 USA

[4] Univ Florida, Inst Brain, Dept Neurosci, Gainesville, FL 32606 USA

来源：

EXPERIMENTAL CELL RESEARCH | 1998年 / 239卷 / 02期

关键词：

D O I：

10.1006/excr.1997.3904

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have previously cloned a novel guanine nucleotide-binding protein (G-protein)-coupled receptor, H218, that has sequence similarity to a lysophosphatidic acid receptor, edg2. We present here Northern analysis indicating that the H218 mRNA is expressed in undifferentiated F9 embryonal carcinoma cells. The H218 message is down-regulated and its stability is decreased during retinoic acid-and dibutyryl cAMP-induced differentiation. Treatment by various receptor-selective retinoids indicated that retinoic acid receptor beta or gamma signaling, but not retinoid X receptor activation, is required for the down-regulation of H218 mRNA. Activation of the H218 receptor may contribute to the phenotype of undifferentiated F9 embryonal carcinoma cells. (C) 1998 Academic Press.

引用

页码：320 / 325

页数：6

共 23 条

[1] Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid [J].